I've looked into doing it into a B-Series Dodge van, it'll take a bit of cutting and fabbing, mainly to properly clear the dash, more than anything.
The Dodge has a very adaptable tranny crossmember support, so even sticking an NV4500 in there looks doable.
I even have the hydro brackets to do it, just not so sure it's practical.
Of course, I could build it as a Trans-Van, ala '70s Custom style.
A Van with a Dodge Truck dually bed might be neat...