300 HP can readily be done and we have several members who have done that. Twin turbos would definitely be in the picture. Might even consider doing this in stages and start with a single turbo. Must remember that diesels are more into torque then HP. A 225 HP Cummins will have as much or more torque than a big block gas engine that may have twice that HP. On the injection pump side, install 3000 or 4000 RPM governor springs, a #10 torque plate, and adjust the timing to 16 deg. Any higher on the timing will risk a blown head gasket unless you do some other mods. You can keep the stock 5x.010 injectors with a single but 5x.012 would be needed for the higher power level. I'd install head studs and if you think the twins are still a viable option consider having the head O ringed. Doing 300 HP will need boost in the 40 PSI range and that's about the limit for a stock head gasket without O rings. There can be several smaller things that can be done to insure longevity. Might have pistons and bearings specialty coated, install new rod bolts, and could add a balancer to the crank. Also, if twin are a go think on an oil pump with more output and a 7 plate oil cooler like came on the 6bt.